Introduction SULFADIAZINE
XX is a topical anti-infective agent with the antibacterial properties of both silver ion and sulfadiazine. Both free silver and the sulfonamide moiety may exert activity, XX is used to prevent and treat infections of wounds caused by second- and third-degree burns. The drug does not inhibit folic acid synthesis as other sulfonamides do, rather disrupts bacteria by damaging the cell membrane and the cell wall. It has a wide spectrum of bactericidal activity against both gram-positive and gram-negative organisms. |
Category: - Dermatological drugs (topical)
- Anti-infectives, topical
- Antibacterials, topical
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Primary Characterstics Silver Sulfadiazine also known as Sulfadiazine, is of Synthetic origin and belongs to Sulphonamide. It belongs to Antibiotics, Other pharmacological group on the basis of mechanism of action and also classified in Antibiotic, Topical pharmacological group.The Molecular Weight of Sulfadiazine is 357.10. |
Pharmacokinetics Oral absorption of Sulfadiazine is found to be 7.5% ±2.5. Volume of distribution is found to be 0.36 l/kg and plasma protien binding is 29 - 45 %. and metabolism is reported Hepatic. Plasma half life is 10 - 12 hr.
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