Introduction PARACETAMOL
XX is analgesic and antipyretic agent. XX is the active metabolite of phenacetin, responsible for its analgesic effect. XX is a weak prostaglandin inhibitor in peripheral tissues and possesses no significant antinflammatory effects. XX is one of the most important drug used for the treatment of mild to moderate pain when an antinfalmmatory effect is not necessary. XX is preferred over aspirin as an analgesic/antipyretic for patients in whom aspirin is contraindicated, such as those who have a history of gastric ulcer or a coagulation disorder. |
Category: - Analgesics, antipyretics, NSAIDs, antigout, and antirheumatics
- Non-opioid analgesics
- Paracetamol
- Antimigraine preparations
- Acute migraine attack
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Primary Characterstics Paracetamol also known as Acetylparaminophenol, Acetaminophen is of Synthetic origin and belongs to Aminophenol. It belongs to Cyclo-oxygenase inhibitor pharmacological group on the basis of mechanism of action and also classified in Analgesics and Anti-inflammatory Agents pharmacological group.The Molecular Weight of Paracetamol is 151.20. Its pKa is 9.5. |
Pharmacokinetics Oral absorption of Paracetamol is found to be 96.5% ±1.5. Volume of distribution is found to be 0.9 l/kg and plasma protien binding is < 20%. Presystemic metabolism is noted to be 20% and metabolism is reported hepatic. Renal Excretion accounts for 5% unchanged and plasma half life is 1.5-3.0 hr.
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