Introduction
DOMPERIDONE
XX is a dopamine blocking agent. XX is antiemetic agent. XX is also used to treat nausea and vomiting induced by cancer chemotherapy. |
Category: - Gastrointestinal drugs
- Antiemetics & antinauseants
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Primary Characterstics
Domperidone is of Synthetic origin and belongs to Benzimidazolin. It belongs to Antiemetic/Antivertigo Agents pharmacological group.The Molecular Weight of Domperidone is 425.90. Its pKa is 7.9. |
Pharmacokinetics
Oral absorption of Domperidone is found to be 46.5% ±46.5. Volume of distribution is found to be 5.7 l/kg and plasma protien binding is 91-93%. Presystemic metabolism is noted to be 85% ±2 and metabolism is reported extensively by liver & Gut. Renal Excretion accounts for major and plasma half life is 12-16 hr (oral), 7.5 hr (parentral).