ORAGIN is the trade name of the combination of Spiramycin, a macrolide antibiotic; and Metronidazole, a 5-nitro-imidazole antibiotic; reserved for buccodental pathological infections.

Each ORAGIN Tablet contains Spiramycin 750,000 international units (IU) and Metronidazole 125 mg.

CHEMISTRY

The main component of Spiramycin is Spiramycin I (4R,5S,6S,7R,9R,10R,11E,13E,16R)-6-[[3,6-dideoxy-4-O-(2,6-dideoxy-3-C-methyl-a-L-ribo-hexopyranosyl)-3-(dimethylamino)-b-D-glucopyranosyl]oxy]-4-hydroxy-5-methoxy-9,16-dimethyl-7-(2-oxoethyl)-10-[[2,3,4,6-tetradeoxy-4-(dimethylamino)-D-erythro-hexopyranosyl]oxy]oxacyclohexadeca-11,13-dien-2-one. Spiramycin II (4-O-acetylspiramycin I) and Spiramycin III (4-O-propanoylspiramycin I) are also present.

Metronidazole is: 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethanol.