DescriptionIndicationsContraIndicationsDosageWarning/Precautions

NORACTONE TABLETS

DESCRIPTION

Introduction

SPIROLACTONE

XX is a potassium-sparing diuretic. XX is a synthetic 17-spirolactone steroid that is competititive antagonist of aldosterone. XX is used as an antihypertensive agent. It frequently is used to treat ascites associated with cirrhosis and also has been used as a diagnostic aid for primary hyperaldosteronism. XX is a poor agent for treating hypertension or generalized edema, although its effects can be additive with thiazide diuretics. It was approved by the FDA in 1960.

Category:

  • Diuretics
  • Potassium sparing diuretics

Primary Characterstics

Spirolactone is of Synthetic origin and belongs to Steroid. It belongs to Aldosterone antagonist pharmacological group on the basis of mechanism of action and also classified in Diuretic Potassium Sparing pharmacological group.The Molecular Weight of Spirolactone is 416.10.
Its pKa is not relevant.

Pharmacokinetics

Oral absorption of Spirolactone is found to be 103% . Plasma protien binding is 98 %. and metabolism is reported Hepatic. Plasma half life is 1.3 +/- 0.3 hr.