Introduction NABUMETONE
XX is a nonsteroidal anti-inflammatory drug. Chemically XX is identified as 4-( 6-methoxy-2-naphthalenyl)-2-butanone. XX is given by mouth in osteoarthritis and rheumatoid arthritis. The drug itself is a relatively weak inhibitor of prostaglandin synthesis, but XX is metabolized in the liver to a more active compound. May thus cause less gastro-intestinal irritation than some other drugs in this class such as indomethacin, but is still contraindicated if there is a history of peptic ulceration. |
Category: - Analgesics, antipyretics, NSAIDs, antigout, and antirheumatics
- Non-opioid analgesics
- Non steroidal anti-inflammatory drugs (NSAIDs)
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Primary Characterstics Nabumetone is of Synthetic origin and belongs to Napthyl Butane. It belongs to Cyclo-oxygenase inhibitor pharmacological group on the basis of mechanism of action and also classified in Analgesics and Anti-inflammatory Agents pharmacological group.The Molecular Weight of Nabumetone is 228.30. |
Pharmacokinetics Oral absorption of Nabumetone is found to be 80% . Volume of distribution is found to be 7.5 l/kg and plasma protien binding is 99 %. Presystemic metabolism is noted to be 100% and metabolism is reported extensive by Liver. Renal Excretion accounts for 80 % and plasma half life is 22 hr.
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