Introduction INDOMETHACIN
XX is NSAID (non-steroidal antinfalmmatory drug). XX is usually regarded as the father figure in the family of non steroidal agents. It relieves pain, reduces inflammation and fever. it, introduced in 1963, is a methylated indole derivative. XX is slightly more toxic but in certain circumstances more effective than aspirin. XX is prepared by chemical synthesis. XX is administered orally. |
Category: - Analgesics, antipyretics, NSAIDs, antigout, and antirheumatics
- Non-opioid analgesics
- Non steroidal anti-inflammatory drugs (NSAIDs)
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Primary Characterstics Indomethacin is of Synthetic origin and belongs to Indole Acetic Acid. It belongs to Cyclo-oxygenase inhibitor pharmacological group on the basis of mechanism of action and also classified in Analgesics and Anti-inflammatory Agents pharmacological group.The Molecular Weight of Indomethacin is 357.80. Its pKa is 4.5. |
Pharmacokinetics Oral absorption of Indomethacin is found to be 50% ±50. Volume of distribution is found to be 1 l/kg and plasma protien binding is 90-99%. Presystemic metabolism is noted to be 45.5% ±4.5 and metabolism is reported Hepatic(extensive). Renal Excretion accounts for 60% and plasma half life is 1-16 hr.
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