XX is an imidazole antifungal agent. It was the first oral azole introduced into clinical use for the treatment of systemic mycoses. It has a broad spectrum of action. XX is active against many Candida species, endemic mycoses and dermatophytes. It was approved by the FDA in 1981.Like other azole antifungals, it exerts its effect by altering the fungal cell membrane.it inhibits ergosterol synthesis by interacting with 14-¢ demethylase, a cytochrome P-450 enzyme that is necessary for the conversion of lanosterol to ergosterol, an essential component of the membrane. |