Methyl dopa is a widely used oral antihypertensive agent. XX is analog of L-dopa. Chemically XX is identified as L-3-(3, 4-dihydroxyphenyl)-2-methylalanine. After crossing the blood-brain barrier, XX is decarboxylated to produce alpha-methylnorepinephrine. This metabolite stimulates central inhibitory alpha-adrenergic receptors, thereby reducing peripheral resistance and lowering blood pressure.it also may act as a false transmitter, thereby exerting a direct effect on peripheral sympathetic nerves. Blood pressure decreases are greatest when the patient is standing but are also significant when the patient is supine. Postural hypotension has been reported in patients receiving it. It can cause sodium and fluid retention, and tolerance can develop during long-term therapy. |