Introduction
FUROSEMIDE
Furosemide is an antihypertensive agent. Furosemide is a prototype drug of Loop Diuretics. Loop diuretics have much greater diuretic effects than thiazides. Furosemide is a sulfonamide derivative. It has a carboxyl group with a sulfamoyl moiety in the meta position. A halide or phenoxy substitution is present at carbon 4, and a substituted amino group is present at carbon 2 or 3. Furosemide is characterized by high efficacy and rapid onset of action. It increases the urination and decrease the amount of water retained in the body. |
Primary Characterstics
belongs to Anthranilic Acid. It belongs to Na-K-Cl triple cotransport inhibitor pharmacological group on the basis of mechanism of action and also classified in Diuretic Loop pharmacological group.The Molecular Weight of Furosemide is 330.70. Its pKa is 3.8. |
Pharmacokinetics
Oral absorption of Furosemide is found to be 64.5% ±2.5. Volume of distribution is found to be 220 ml/kg and plasma protien binding is 97%. and metabolism is reported partly. Renal Excretion accounts for major and plasma half life is 45-60 min.