Introduction
BUSPIRONE
XX is anxiolytic agent and a 5-HT 1 agonist. XX is a new non-benzodiazepine. It relieves nervousness, anxiety. Unlike benzodiazepines the drug has less side effects. |
Category: - Psychotherapeutic drugs
- Drugs used in anxiety and sleep disorders
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Primary Characterstics
Buspirone is of Synthetic origin and belongs to Pyrimidinyl piperazinyl decane. It belongs to 5HT-1A antagonist pharmacological group on the basis of mechanism of action and also classified in Psychotherapeutic Drugs and Antianxiety Agent pharmacological group.The Molecular Weight of Buspirone is 422.00. Its pKa is 1.22, 7.32. |
Pharmacokinetics
Oral absorption of Buspirone is found to be 100% . Volume of distribution is found to be 5.3 l/kg and plasma protien binding is 95%. Presystemic metabolism is noted to be 96% and metabolism is reported extensive via liver. Renal Excretion accounts for 65% and plasma half life is 2-11hr.